Click here to go to our fundraising page Our Message This year we are proudly supporting The Terry Fox Foundation in its ongoing work to fund innovative and progressive cancer research programs by taking part in the 35th Anniversary Terry Fox Run. To learn more about this amazing event click here. Please support our ... Read More
Ronald Wu, PhD Candidate, was awarded best poster Adrien C. Begg Award at the The 14th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology held in Switzerland from Saturday, June 20, to Monday, June 22, 2015.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER Twan van den Beucken, Elizabeth Koch, Kenneth Chu, Rajesha Rupaimoole, Peggy Prickaerts, Michiel Adriaens, Jan Willem Voncken, Adrian L. Harris, Francesca M. Buffa, Syed Haider, Maud H. W. Starmans, Cindy Q. Yao, Mircea Ivan, Cristina Ivan, Chad V. Pecot, Paul C. Boutros, ... Read More
J Enzyme Inhib Med Chem. 2014 Oct 27:1-33. Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. Pettersen EO1, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ,Peso LD, ... Read More
Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG. PLoS One. 2014 Feb 28;9(2):e89997. doi: 10.1371/journal.pone.0089997. eCollection 2014. Abstract The cellular response to DNA double strand breaks (DSBs) involves the ordered assembly of repair proteins at or near sites of damage. This process is mediated through post-translational protein modifications that include both phosphorylation and ubiquitylation. Recent ... Read More
Clin Cancer Res. 2013 Dec 15;19(24):6741-50. doi: 10.1158/1078-0432.CCR-13-1787. Epub 2013 Oct 18. Zannella VE1, Dal Pra A, Muaddi H, McKee TD, Stapleton S, Sykes J, Glicksman R, Chaib S, Zamiara P, Milosevic M, Wouters BG, Bristow RG, Koritzinsky M. Abstract PURPOSE: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal ... Read More
Koritzinsky M, Levitin F, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG. J Cell Biol. 2013 Nov 18. Full text. Abstract Most proteins destined for the extracellular space require disulfide bonds for folding and stability. Disulfide bonds are introduced co- and post-translationally in endoplasmic reticulum (ER) cargo in a redox relay that requires a terminal electron acceptor. Oxygen can serve as the electron ... Read More
Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 Mujcic H, Nagelkerke A, Rouschop KM, Chung S, Chaudary N, Span PN, Clarke B, Milosevic M, Sykes J, Hill RP, Koritzinsky M, Wouters BG. Clin Cancer Res. 2013 Nov 15;19(22):6126-37. Abstract Purpose: Conditions of poor oxygenation (hypoxia) are present in many human tumors, including cervix cancer, and are associated with increased ... Read More